PLA2s reMorroniside present a superfamily of lipolytic enzymes which specifically catalyze the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, resulting in the Chlorothiazide generation of fatty acids and lysophospholipids. Apart from their primary catalytic function, snake venom PLA2s often display additional pharmacological activities that may be independent of catalytic activity. Hemorrhagic, myotoxic, hemolytic, edematogenic and neurotoxic activities, among others, are described for PLA2, implicating the action of PLA2s in many of the pharmacological effects seen in snake envenomation. Several studies have demonstrated that the PLA2 from Bothrops venoms are involved in inflammatory responses such as edema, pain, leukocyte migration, necrosis and myotoxicity. PLA2 may be classified as Asp49 or Lys49 PLA2, depending on the residue at position 49 in the amino acid sequence. Asp49 PLA2s are enzymatically active whereas Lys49 PLA2s show little or no enzyme activity, although both types are biologically active. In the phospholipase activity tested in the present study, obviously, only the function of Asp49 PLA2s were evaluated. In the experiment, the aqueous leaf extract of J. gossypiifolia was inactive. In the higher concentration tested, the extract inhibited the phospholipase activity at about 15%, however, this inhibition was not statistically significant. One possible hypothesis is that the extract could present more affinity to enzymatically inactive phospholipases, i.e., Lys49 PLA2. So, the in vivo edematogenic and myotoxic activities were also investigated. Bothropic envenomation is characterized by the rapid development of edema and inflammation at the site of venom inoculation. The intraplantar injection of B. jararaca venom induces an edematogenic response that appears to be mediated primarily by cyclooxygenase and lypoxygenase eicosanoid products and, in minor extent, evolves the participation of histamine, serotonin and platelet-activating factor. Leucocytes exert an important role in the inflammatory response produced in paw edema, being capable of secreting endogenous pro-inflammatory mediators relevant to the acute inflammation development.