We used the Hackett��s score since when the study was started, in 1991, the Lake Louise score was not yet in use for epidemiological studies of AMS. Besides, the Hackett��s score has been highly correlated to the Lake Louise score and the Environmental Symptoms Questionnaire for the clinical evaluation of AMS. Although we included a long list of potential predictor variables and established which factors remain independent after adjustment and their relative importance, a residual confounding bias may persist. Finally, this study was conducted from a single outpatient altitude medicine consultation and its transportability has to be evaluated in other populations, by means of an external validation. However, the recruitment of this consultation comes from all regions of France and surrounding French-speaking countries. Quadruplex DNAs have been implicated in a number of biological processes. Quadruplex DNA has been proposed to be important in U0126 telomere structure and function, in the regulation of gene expression and in some triplet repeat diseases. The importance of these biological roles and the variety of quadruplex structures has given rise to interest in finding drug like (+)-JQ1 molecules that bind to specific quadruplex DNAs for use as potential leads for therapeutic intervention and as research tools to investigate the presence and functions of quadruplex DNA in cells and other complex systems such as shelterin. The structures of the complexes of quadruplex DNAs are also of interest in the development of sensors based on aptamers that contain quadruplex structures. Moderate to high throughput screening of drug like molecules against a target can be a first step in identifying potentially useful candidates. Initial screening is typically designed to find all, or almost all, candidate molecules that are then subject to further scrutiny. Quite a number of methods have been developed that screen molecules for their binding to quadruplex DNAs. We have designed a screening method that aims to identify molecules that preferentially bind to quadruplex structural types. Methods have been developed to screen for accurate monitoring of telomerase inhibition and for the presence of quadruplex DNA in vivo.