Unless stated otherwise, confidence LY2835219 intervals are presented in the figures and standard deviation in the text while the p value found in the text is adjusted for both age and sex. All analyses were carried out using SPSS version 17.0 and a p, 0.05 was considered significant. Multimorbidity is a condition affecting an important proportion of the population. While multimorbidity has been shown to increase with age, its longitudinal evolution is less investigated. The present study reports a multimorbidity prevalence of 32% that doubled over a mean 7.8 years of follow-up to reach 64%. This important increase in multimorbidity prevalence is in line with a recent systematic review, that reported that multimorbidity prevalence increases with aging, with the highest rise between age 40 and 70. Therefore, the present study, using a longitudinal design, confirms the steep and important increased in the prevalence of multimorbidity with aging reported in cross sectional studies. Also, the proportion of those with at least one CD was found to be similar to those observed in general practitioner populations but higher than those estimated in the general population. This study also presents differences in the mean age of onset for eight CDs in the same population. Briefly, the mean age of onset of asthma, hypercholesterolemia and other mental disorders is younger while COPD, CVD and hypertension is older. While mental disorders are known to occur at a young age, it is surprising that mood and anxiety disorders are not frequent in the younger age group, particularly considering that their respective mean age of onset has been previously estimated to be 11 years for anxiety and 30 years for mood disorders. The reported mean age of onset of diabetes, asthma and COPD are in line with previous publications. The present observations result from incident cases from individuals over 18 years old and do not take into account the age of onset of CDs already present at baseline. Despite these limits, the mean age of onset is important in understanding the evolution of multimorbidity and can be used to compare factors associated with CD ABT-199 1257044-40-8 occurrence.