As firstly, the Renin-Angiotensin-Aldosterone System can activate oxidative stress, thus contributing Darunavir significantly to the deterioration of cardiovascular function, and eventually lead to myocardial remodeling. In this pathway, NADPH oxidase is a crucial factor for bridging RAAS and oxidative stress progress by generating the reactive oxygen species in virtual hypertrophy and remodeling of chronic HF. It is also a potential therapeutic target in HF cases. Secondly, HF has been regarded, in the past decades, as a complex cascade of chronic inflammatory reactions that caused gradual cardiac depression. Besides, recent extensive investigations revealed that cytokines, such as tumor necrosis factor-a and interleukin-6 had important impacts on cardiac outcome as inflammatory markers. Among them, TNF-a has been considered to have detrimental effects on myocardial function by NF-B and eventually result in VR. Numerous studies have also shed light on the role of IL-6 in cardiovascular disease, as long-term IL-6 levels are highly associated with HF by prolongation of STAT signaling, especially STAT3, in cardiacmyocytes. They are also applied as promising molecular targets to treat HF. Traditional Chinese medicine has been applied to treat HF for thousands of years, and some herbal formulas have been proven to be effective. Qishenyiqi, one of the most well-known TCM formula, prepared from a composition of six herbs of TCM, SCH 619734 including two star herbs, Radix Astragali mongolici and Salvia miltiorrhizabunge, and four other adjunctive herbs: Flos Lonicerae, Scrophularia, Radix Aconiti Lateralis Preparata, and Radix Glycyrrhizae. This formula is widely manufactured in China in accordance with the China Pharmacopoeia standard of quality control, and is commonly applied in routine treatment of HF in China. Randomized, controlled clinical trials proved that it has a definite effect on improving heart function. Our previous study demonstrated that QSYQ can ameliorate myocardial hypertrophy and remodeling by inhabiting the expression of angiotensin II in LAD rats, improving hemorrheology in HF animals, and suppressing angiotensin II receptor levels.