These globular complexes have been utilized in cancer treatment, wound healing, and in the prevention of HIV transmission. Likewise, CDs, are a class of macrocyclic molecular containers that have been extensively studied for their use in drug delivery. These compounds have also been demonstrated to increase drug solubility in water and enhance the absorption of anticancer drugs. In summary, drug delivery systems may improve drug bioavailability by altering the solubility of a drug in water, stability during storage or in vivo, toxicity, side effects, drug resistance, absorption and also by providing specific targeting options to specify distribution and thus improve drug efficiency. Over the past Ranolazine decade a new class of molecular containers known as cucurbiturils have been studied intensively because their intriguing recognition properties render them prime components for academic applications including the development of chemical sensors and molecular machines and also due to their potential to supplant the cyclodextrins as an effective drug delivery system. The preclinical stage of drug discovery is an integral part of the drug discovery process and is a necessary step in the development of CB type molecular containers as a novel drug delivery system. This stage of the drug discovery process involves the understanding of the candidate��s specific features such as the ability to cross crucial membranes, metabolic stability and their ability to pass a series of in vitro and in vivo toxicity screens to assess Rolipram safety in the human system. Drug toxicology is a crucial aspect of drug discovery because only about 1 out of 5,000 screened drugs are approved for medicinal use due to the fact that most drugs fail toxicology assays conducted on animals. Although the analysis of the chemical and biological significance of container-drug complexes of CBs with albendazole, platinum-based anticancer drugs, Vitamin B and antibiotics such as proflavine have been reported, there is very little information reported about the toxicology of the empty CB containers.