This result was interpreted as suggesting the presence of two different kinds of inclusions, one with less and one with more immobile a-synuclein protein. We interpret these data similarly, and suggest that there are at least two pools of Syn-GFP in the terminals, one of which has substantially less mobility than the others. Interestingly, however, the high intensity terminal population that has a lower mobility is the same population that shows some evidence for terminal loss over time. Our work describes a new model system for studying the biology of a-synuclein in the living brain over a period of months with single cell and even single synapse resolution. The data demonstrate the stability of expression of Syn-GFP within neurons in this transgenic line over time and provide the first in vivo measurements of a-synuclein mobility within neurons and terminals. The ability to study a-synuclein with this new level of 17 alpha-propionate specificity holds the promise of revealing SC79 important insights into the pathobiology of Parkinson��s Disease and related synucleinopathies. The domesticated silkworm, Bombyx mori, is the lepidopteran model species and is an economically important insect used for silk production and proteinaceous drug expression. However, Bombyx mori nucleopolyhedrovirus, as a natural viral pathogen for the silkworm, causes heavy larval mortality and enormous losses to the sericulture industry. Furthermore, no effective therapeutic means are available currently to control BmNPV infection. BmNPV belongs to the Baculoviridae family of rod-shaped enveloped viruses. During the baculovirus infection cycle, it produces two types of virions, budded viruses and occlusion-derived viruses. These two virion types contain identical genomic information and nucleocapsid structures but different viral envelopes, as they are produced at different stages of the virus life cycle. BVs are responsible for systematic infection within the silkworm, while ODVs mediate horizontal transmission between hosts. Baculovirus BVs enter host cells via a receptor-dependent endocytosis pathway at approximately 1 h post-inoculation.