It is conceivable that some of the pathophysiological Pentyl Chloroformate changes developing during exposure to psychosocial chronic stress reflect sleep disturbances. Some studies suggest that MCP1, EGF en VEGF levels may indeed be related with sleep quality, and be altered as an effect of disrupted sleep. It would be therefore important to test a correlation of MCP1, EGF and VEGF levels in relationship to qualitative and quantitative sleep alterations. Taken together with the recently reported dexamethasoneCRH data, our results indicate that women under prolonged psychosocial stress develop so-far unique neuro-endocrine-immune alterations. Due to the retrospective observational nature of the study, the Regional ethics committee of Mid-Norway had no comment to the study, and as the examinations themselves were part of a clinical quality assurance program, they did not need formal approval from the ethics committee. However, all patients gave oral consent to the use of clinical data for research purposes. Five patients had hereditary hemochromatosis and one had hemosiderosis secondary to excessive iron intake. Hence 34 patients had no hfe-mutation known to predispose for hemochromatosis and was further examined to reveal other causes for hyperferritinemia. Hepatic iron overload was present in only 4 patients. These had also slightly elevated transferrin saturation. In two of them increased iron stores were explained by alcohol consumption. Liver histology, transferrin saturation, and number of phlebotomies needed to normalize s-ferritin, indicated normal iron-load in the remaining population. There was no sign of inflammation or malignancy. Steatohepatitis was found in three patients. One of these was diagnosed as NASH. The majority of the study population Alprostadil showed markers of the metabolic syndrome. BMI, waist-hip ratio, diastolic blood pressure, ALT, HDL-cholesterol, fasting plasma glucose and insulin C-peptide showed deviations typically seen in the metabolic syndrome. Elevated insulin C-peptide levels indicate hyperinsulinemia and insulin resistance. Liver histology showed steatosis and nuclear glycogen inclusions, a typical finding in prediabetes and DM2.