Our results underscore two features that could be useful in this respect. However, due to the nature of the data analyzed in this work, our results are particularly relevant to hematological malignancies, which are overrepresented in our dataset. FAAH, the enzyme responsible for the degradation of AEA, was expressed only in theca cells of secondary and tertiary follicles, the corpus luteum and corpus albicans. Cernnunos/XLF is a recently discovered NHEJ core factor which acts as part of the Ligase IV/XRCC4 complex and bares structural similarity to XRCC4. Cernnunos/XLF has been shown in vitro to stimulate the ligation process by the Ligase IV/ XRCC4 complex. Cernnunos/XLF deficient mouse embryonic fibroblasts are highly sensitive to IR and show increased chromosomal abnormalities implicating the importance of Cernnunos/XLF in preventing genomic instability under normal growth conditions. Mutations in the human Cernnunos/XLF gene cause combined immunodeficiency, due to a defect in VJ recombination which leads to decreased numbers of mature T- and B- lymphocytes. Fibroblasts from patients carrying Cernunnos/XLF mutations are radio-sensitive and exhibit impaired DSB repair following IR or radiomimetic drug treatment. These data suggest that AEA is acting in an autocrine manner on the granulosa cell to stimulate unknown phenotypic changes, and that an alternative degradation pathway that does not involve FAAH may be present in the granulosa cell. Indeed, recent evidence suggests that AEA can be CYT387 converted to a prostaglandin E2-ethanolamine through the actions of cyclooxygenase 2, an enzyme that is expressed in the ovarian granulosa cell and which is under leptin control. Chromosomal translocations have been difficult to find in solid tumors, particularly in epithelial cancers, due to the presence of complex karyotypes with many aberrations that are difficult to analyze. However, gene fusions with clear oncogenic potential have been recently identified in prostate and lung cancers , suggesting that such rearrangements might be of greater importance for the development of solid tumors than generally thought. It will be interesting to see whether our findings also apply to solid malignancies, as more genomes from primary tumors are sequenced. L-proline, a relevant energy source in trypanosomatids, is metabolized and converted into five intermediates of the tricarboxylic acid cycle through its oxidation to glutamate in T. cruzi. Analogues of proline could be useful for inhibition of enzymes of this and other metabolic pathways. Among these analogues, Lthiazolidine-4-carboxylic acid, a product of the non-enzymatic condensation of equimolar quantities of formaldehyde and Lcysteine to yield the saturated imino acid containing S as a thioether , has the ability to interfere with the utilization of proline for protein synthesis and to mimic proline in its incorporation into proteins. It can be metabolized in both bacterial and mammalian cells.